Does Grapefruit Affect Vitamin A?

Amount or timing may matter

The short answer

Retinol is partially metabolized by CYP3A4. Grapefruit may increase vitamin A levels, raising hepatotoxicity risk at higher doses.

How to arrange timing

Separate high-dose vitamin A from grapefruit by at least 4 hours.

Reference

Reference noted for this food and supplement combination: Ross AC, J Nutr 2012; Examine.com

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.