Does Caffeine Affect Passionflower?

Amount or timing may matter

The short answer

Passionflower acts via GABA-A receptor modulation to promote relaxation. Caffeine antagonizes this mechanism.

How to arrange timing

Avoid caffeine at least 6 hours before taking passionflower for anxiety or sleep.

Reference

Reference noted for this food and supplement combination: NIH NCCIH 2024; Examine.com

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.