Does Caffeine Affect Melatonin Extended Release?

Amount or timing may matter

The short answer

Extended-release melatonin requires sustained effect throughout the night. Caffeine's long half-life (5-6h) means it can disrupt melatonin's action for hours.

How to arrange timing

Avoid caffeine at least 8 hours before taking extended-release melatonin.

Reference

Reference noted for this food and supplement combination: NIH ODS 2024; Burke et al. 2015

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.