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Does Caffeine Affect L-Tryptophan?
Amount or timing may matter
The short answer
L-tryptophan is a serotonin/melatonin precursor used for sleep. Caffeine's stimulant effect opposes the sedation pathway.
How to arrange timing
Take L-tryptophan at least 4 hours after your last caffeine intake.
Reference
Reference noted for this food and supplement combination: NIH ODS 2024; Examine.com
Important context
The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.