Does Caffeine Affect Kava?

Amount or timing may matter

The short answer

Kava's anxiolytic effects work through GABA pathways. Caffeine's adenosine antagonism and cortisol elevation counteract kava's calming properties.

How to arrange timing

Separate kava from caffeine by at least 6 hours.

Reference

Reference noted for this food and supplement combination: Examine.com 2024

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.