Does Caffeine Affect Holy Basil?

Amount or timing may matter

The short answer

Holy basil (tulsi) is an adaptogen that lowers cortisol and promotes calm. Caffeine raises cortisol and activates the HPA axis, counteracting these benefits.

How to arrange timing

Separate holy basil from caffeine by at least 2 hours for stress-relief benefit.

Reference

Reference noted for this food and supplement combination: Examine.com 2024; Cohen 2014

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.