Does Caffeine Affect Creatine?

May affect absorption or how you feel

The short answer

Caffeine's diuretic effect may counteract creatine's intracellular hydration mechanism, potentially reducing creatine uptake into muscles.

How to arrange timing

Stay well-hydrated when combining. Some studies show caffeine may blunt creatine's ergogenic benefit.

Reference

Reference noted for this food and supplement combination: Vandenberghe et al. 1996; Examine.com 2024

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.