Does Caffeine Affect Chamomile?

Amount or timing may matter

The short answer

Apigenin in chamomile binds GABA-A receptors for mild sedation. Caffeine's adenosine antagonism opposes this calming effect.

How to arrange timing

Separate chamomile from caffeine by at least 4 hours for relaxation benefit.

Reference

Reference noted for this food and supplement combination: Srivastava et al. 2010; Examine.com

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.