Does Alcohol Affect Melatonin?

Use extra care with this combination

The short answer

Alcohol combined with melatonin causes excessive CNS depression and disrupts sleep architecture.

How to arrange timing

Never combine alcohol with melatonin; both are CNS depressants.

Reference

Reference noted for this food and supplement combination: FDA

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.