Can You Take St. John's Wort and Valerian Root Together?

Dose or timing may matter

The short answer

Both have CNS-active effects. Combining may cause excessive sedation or unpredictable interactions.

How to arrange timing

Avoid combining without medical guidance.

Reference

Reference noted for this combination: NCCIH 2024

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.