Can You Take Retinyl Palmitate and Vitamin D3 Together?

Dose or timing may matter

The short answer

Retinyl palmitate is an ester form of preformed vitamin A. High-dose preformed vitamin A antagonizes vitamin D at the VDR receptor level, reducing vitamin D's effects on calcium metabolism and immune function.

How to arrange timing

Avoid mega-dosing retinyl palmitate if taking vitamin D3. Standard doses of both are fine together.

Reference

Reference noted for this combination: Johansson S, Melhus H. Vitamin A antagonizes calcium response to vitamin D in man. J Bone Miner Res. 2001;16(10):1899-1905

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.