Can You Take Resveratrol and Vitamin B3 Together?

Dose or timing may matter

The short answer

Resveratrol activates SIRT1 (a sirtuin deacetylase) which consumes NAD+ as a substrate. Combined with niacin (B3), which also feeds into the NAD+ pool, this may create unpredictable effects on NAD+ metabolism and cellular energy balance.

How to arrange timing

Research suggests these may have complex interactions; monitor energy and metabolic markers if combining.

Reference

Reference noted for this combination: Howitz KT et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003;425(6954):191-196

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.