Can You Take Palmitoylethanolamide and Valerian Root Together?

Dose or timing may matter

The short answer

PEA has mild calming and anti-neuroinflammatory effects, while Valerian Root is a GABAergic sedative. The combination may produce additive sedation that could impair alertness.

How to arrange timing

If using both, take them in the evening before bed. Avoid driving or operating machinery after combining.

Reference

Reference noted for this combination: Gabrielsson L, et al. Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy. Br J Clin Pharmacol. 2016;82(4):932-942.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.