Can You Take Nicotinamide Riboside and Resveratrol Together?

Dose or timing may matter

The short answer

Nicotinamide riboside (NR) raises NAD+ levels via the salvage pathway, while resveratrol activates SIRT1 which consumes NAD+ as a co-substrate. At high resveratrol doses, SIRT1 activation may outpace NR-driven NAD+ replenishment.

How to arrange timing

Balance nicotinamide riboside and resveratrol doses to ensure NAD+ supply meets increased demand.

Reference

Reference noted for this combination: Cantó C et al. The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab. 2012;15(6):838-847

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.