Can You Take Naringenin and Vitamin C Together?

Dose or timing may matter

The short answer

Naringenin inhibits CYP3A4 and intestinal drug transporters, while Vitamin C is a CYP3A4 substrate. Naringenin may alter Vitamin C metabolism and reduce the effectiveness of Vitamin C as a pro-oxidant recycler.

How to arrange timing

Consider separating Naringenin and Vitamin C by 1-2 hours if using therapeutic doses.

Reference

Reference noted for this combination: Bailey DG, et al. Grapefruit-medication interactions: forbidden fruit or avoidable consequences? CMAJ. 2013;185(4):309-316.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.