Can You Take NAC and Selenium Together?

Dose or timing may matter

The short answer

N-acetylcysteine can form selenotrisulfide compounds with selenium, potentially reducing selenium bioavailability for glutathione peroxidase synthesis and other selenoprotein functions.

How to arrange timing

If supplementing both NAC and selenium, consider taking them separately to optimize selenium utilization.

Reference

Reference noted for this combination: Burk RF et al. Selenoprotein metabolism and function. Free Radic Biol Med. 2015;79:101-108

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.