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Can You Take Methylcobalamin and Vitamin C Together?
May affect absorption
The short answer
High-dose vitamin C (≥500 mg) can degrade methylcobalamin in the GI tract. The methyl group on methylcobalamin is particularly susceptible to oxidative cleavage by ascorbic acid, generating inactive cobalamin analogs.
How to arrange timing
Space methylcobalamin and high-dose vitamin C at least 2 hours apart, or take methylcobalamin sublingually to bypass GI interaction.
Reference
Reference noted for this combination: Herbert V, Jacob E. Destruction of vitamin B12 by ascorbic acid. JAMA. 1974;230(2):241-242
Important context
Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.