Can You Take Melatonin Extended Release and St. John's Wort Together?

Use extra care with this pair

The short answer

Melatonin Extended Release provides sustained melatonin levels (a serotonin metabolite), and St. John's Wort increases serotonin. The prolonged exposure may amplify serotonergic stacking effects.

How to arrange timing

Be cautious when combining Melatonin Extended Release with St. John's Wort. The extended-release form prolongs the interaction window.

Reference

Reference noted for this combination: Foley HM, Steel AE. Adverse events associated with oral administration of melatonin. Complement Ther Med. 2019;42:65-81.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.