Can You Take Melatonin and Yerba Mate Together?

Dose or timing may matter

The short answer

Yerba mate contains caffeine and theobromine which may counteract melatonin's sleep-promoting effects.

How to arrange timing

Avoid yerba mate in the evening if taking melatonin for sleep.

Reference

Reference noted for this combination: Heck & de Mejia, 2007, J Food Sci

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.