Can You Take Melatonin and Wild Lettuce Together?

Use extra care with this pair

The short answer

Wild lettuce's sedative lactucarium combined with melatonin may lead to excessive drowsiness.

How to arrange timing

Start with low doses if combining.

Reference

Reference noted for this combination: Wesolowska et al., 2006, J Ethnopharmacol

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.