Can You Take Melatonin and Theobromine Together?

Dose or timing may matter

The short answer

Theobromine is a mild CNS stimulant that may counteract melatonin's sleep-inducing effects.

How to arrange timing

Avoid theobromine in the evening if using melatonin for sleep.

Reference

Reference noted for this combination: Baggott et al., 2013, Psychopharmacology

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.