Can You Take Melatonin and Theacrine Together?

Dose or timing may matter

The short answer

Theacrine activates dopamine and adenosine pathways for alertness, which may counteract melatonin's sleep-promoting effects.

How to arrange timing

Use theacrine in the morning and melatonin at bedtime.

Reference

Reference noted for this combination: Feduccia et al., 2012, J Ethnopharmacol

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.