Can You Take Melatonin and Synephrine Together?

Dose or timing may matter

The short answer

Synephrine is a sympathomimetic stimulant that may counteract melatonin's sleep-promoting effects.

How to arrange timing

Avoid synephrine in the evening if taking melatonin for sleep.

Reference

Reference noted for this combination: Stohs et al., 2012, Phytother Res

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.