Can You Take Melatonin and Skullcap Together?

Use extra care with this pair

The short answer

Skullcap's baicalin enhances GABAergic activity; combining with melatonin may cause excessive sedation.

How to arrange timing

Reduce doses if combining; avoid activities requiring alertness.

Reference

Reference noted for this combination: Awad et al., 2003, Phytomedicine

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.