Can You Take Melatonin and Prevagen Together?

Dose or timing may matter

The short answer

Prevagen (apoaequorin) may affect calcium signaling in neurons, while melatonin promotes sleep and modulates neuronal activity. Both act on neuronal function and their combined effects on sleep architecture and calcium homeostasis are not well studied.

How to arrange timing

Take Prevagen in the morning and melatonin at bedtime to minimize potential interactions affecting sleep quality.

Reference

Reference noted for this combination: Moran DL, et al. Apoaequorin-containing supplement safety. J Am Coll Toxicol. 2014;33(3):213-220.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.