Can You Take L-Tryptophan and Selank Together?

Dose or timing may matter

The short answer

Selank modulates serotonin metabolism and may increase serotonin levels, while L-Tryptophan is a serotonin precursor. Combining two serotonin-enhancing agents may lead to excessive serotonergic tone.

How to arrange timing

Monitor for signs of serotonergic excess (agitation, sweating, tremor) when combining Selank with L-Tryptophan.

Reference

Reference noted for this combination: Kozlovskii II, Danchev ND. The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats. Neurosci Behav Physiol. 2003;33(7):639-643.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.