Can You Take SAMe and L-Tryptophan Together?

Dose or timing may matter

The short answer

Both increase serotonin via different pathways. Additive risk of excess serotonin.

How to arrange timing

Avoid combining without medical supervision.

Reference

Reference noted for this combination: Examine.com 2024

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.