Can You Take L-Arginine and L-Citrulline DL-Malate (2:1) Together?

Use extra care with this pair

The short answer

L-Citrulline DL-Malate is converted to L-Arginine in the kidneys, which then produces nitric oxide. Taking additional L-Arginine alongside provides redundant NO precursors, potentially causing excessive vasodilation and hypotension.

How to arrange timing

Research suggests choosing either L-Citrulline DL-Malate or L-Arginine rather than combining both for NO production.

Reference

Reference noted for this combination: Schwedhelm E, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine. Br J Clin Pharmacol. 2008;65(1):51-59.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.