Can You Take Idebenone and Vitamin E Together?

May affect absorption

The short answer

Idebenone and Vitamin E are both fat-soluble quinone/tocopherol antioxidants that compete for micellar incorporation during intestinal absorption, potentially reducing the bioavailability of both.

How to arrange timing

Separate Idebenone and Vitamin E by at least 2 hours to optimize absorption of both.

Reference

Reference noted for this combination: Gueven N, et al. Idebenone: When an antioxidant is not an antioxidant. Redox Biol. 2015;6:595-609.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.