Can You Take Glycine and Magnesium Together?

Use extra care with this pair

The short answer

Both Glycine and Magnesium promote relaxation and have calming effects on the nervous system. Magnesium modulates NMDA receptors while glycine is a co-agonist at the glycine site. Stacking may enhance sedative effects.

How to arrange timing

Use lower doses of each when combining Glycine and Magnesium, particularly before bedtime.

Reference

Reference noted for this combination: Bannai M, et al. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Front Neurol. 2012;3:61.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.