Can You Take Gamma-Butyrolactone and Melatonin Together?

Use extra care with this pair

The short answer

GBL converts to GHB, a potent CNS depressant. Melatonin also has sedative effects. Combining these sedative agents may produce excessive CNS depression, respiratory suppression, and dangerous levels of sedation.

How to arrange timing

Avoid combining GBL with melatonin due to additive CNS depression risks. If both are used, separate them by many hours and use minimal doses.

Reference

Reference noted for this combination: Zvosec DL, et al. Adverse events, including death, associated with the use of 1,4-butanediol. N Engl J Med. 2001;344(2):87-94.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.