Can You Take Ergothioneine and Selenium Together?

Use extra care with this pair

The short answer

Ergothioneine and selenium are both intracellular antioxidants that protect against oxidative stress. Stacking high doses may excessively suppress oxidative signaling needed for immune function and cellular adaptation.

How to arrange timing

When combining Ergothioneine and selenium, use moderate doses of each to avoid excessive antioxidant suppression of adaptive signaling.

Reference

Reference noted for this combination: Halliwell B. The antioxidant paradox: less paradoxical now? Br J Clin Pharmacol. 2013;75(3):637-644.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.