Can You Take Green Tea Extract (EGCG) and Skullcap Together?

Use extra care with this pair

The short answer

Both EGCG and Skullcap have hepatotoxicity reports. High-dose EGCG causes oxidative liver injury, while Skullcap's flavonoids may cause liver damage (possibly exacerbated by germander contamination in some products).

How to arrange timing

Monitor liver function if combining. Ensure Skullcap products are from reputable sources free of germander contamination.

Reference

Reference noted for this combination: Navarro VJ et al., Hepatology 2017; LiverTox (NIH/NLM)

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.