Can You Take Diosmin and Vitamin C Together?

Use extra care with this pair

The short answer

Diosmin is often combined with hesperidin for vascular health. Adding high-dose Vitamin C may amplify the blood vessel permeability-reducing effects, potentially leading to excessive vasoconstriction in some individuals.

How to arrange timing

When combining Diosmin with high-dose Vitamin C, monitor for signs of excessive vascular effects. Moderate doses are generally well-tolerated.

Reference

Reference noted for this combination: Garner RC, et al. Flavonoids and their interactions with other nutrients. Nutr Res Rev. 2005;18(1):4-24.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.