Can You Take D-Serine and L-Serine Together?

May affect absorption

The short answer

D-Serine and L-Serine share the same amino acid transporters (ASC system). Co-administration causes direct absorption competition, reducing the bioavailability of both isomers.

How to arrange timing

Separate D-Serine and L-Serine intake by at least 1 hour for optimal absorption.

Reference

Reference noted for this combination: Kanai Y, Hediger MA. The glutamate/neutral amino acid transporter family SLC1. Pflugers Arch. 2004;447(5):469-479.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.