Can You Take D-Serine and Glycine Together?

Dose or timing may matter

The short answer

D-Serine and Glycine both act as co-agonists at the NMDA receptor glycine binding site. They compete for the same receptor binding site, and co-administration may reduce the effectiveness of each by competitive occupancy.

How to arrange timing

Research suggests choosing either D-Serine or Glycine for NMDA receptor modulation, as they compete for the same binding site.

Reference

Reference noted for this combination: Wolosker H. D-serine regulation of NMDA receptor activity. Sci STKE. 2006;2006(356):pe41.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.