Can You Take Collagen Peptides and Peptidase Together?

Dose or timing may matter

The short answer

Peptidase specifically cleaves peptide bonds and can break down collagen peptides into individual amino acids, potentially eliminating the bioactive peptide benefits of collagen supplementation.

How to arrange timing

Take collagen peptides at least 1 hour apart from peptidase supplements to preserve bioactive peptide structure.

Reference

Reference noted for this combination: Iwai K, et al. Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. J Agric Food Chem. 2005;53(16):6531-6536.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.