Can You Take Collagen and Neutral Protease Together?

Dose or timing may matter

The short answer

Neutral Protease can hydrolyze collagen in the digestive tract at neutral pH, potentially breaking down collagen supplements before they are absorbed as bioactive peptides.

How to arrange timing

Separate collagen supplements from Neutral Protease by at least 1 hour. Take collagen on an empty stomach.

Reference

Reference noted for this combination: Rao MB, et al. Molecular and biotechnological aspects of microbial proteases. Microbiol Mol Biol Rev. 1998;62(3):597-635.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.