Can You Take Citrulline Silicate and L-Arginine Together?

Use extra care with this pair

The short answer

Citrulline silicate provides citrulline which converts to arginine in vivo. Supplementing exogenous arginine on top doubles the nitric oxide substrate, potentially causing excessive vasodilation and hypotension.

How to arrange timing

Choose one or the other. Citrulline silicate already provides sustained arginine levels via the citrulline-arginine cycle.

Reference

Reference noted for this combination: Kalman D et al. A clinical evaluation to determine the safety, pharmacokinetics, and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement. Clin Pharmacol. 2015;7:103-109

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.