Can You Take Citrulline Malate and Citrulline Silicate Together?

Use extra care with this pair

The short answer

Both citrulline malate and citrulline silicate provide citrulline that converts to arginine and boosts nitric oxide. Stacking both forms leads to excessive NO production, potentially causing hypotension, flushing, and headaches.

How to arrange timing

Use only one form of citrulline supplement at a time. There is no benefit to combining different citrulline salts.

Reference

Reference noted for this combination: Kalman D et al. A clinical evaluation to determine the safety, pharmacokinetics, and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement. Clin Pharmacol. 2015;7:103-109

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.