Can You Take Citrulline and Garlic Extract Together?

Dose or timing may matter

The short answer

Citrulline increases nitric oxide via the arginine-NOS pathway while garlic lowers blood pressure via allicin and hydrogen sulfide signaling. Combined use may produce additive hypotensive effects.

How to arrange timing

Monitor blood pressure when combining. May be beneficial for hypertension but could cause excessive BP drops in normotensive individuals.

Reference

Reference noted for this combination: Schwedhelm E et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine. Br J Clin Pharmacol. 2008;65(1):51-59

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.