Can You Take CDP-Choline (Citicoline) and Uridine Monophosphate Together?

Dose or timing may matter

The short answer

CDP-Choline is metabolized into uridine and choline in the body. Adding standalone Uridine Monophosphate creates a redundant uridine load. While often stacked, excessive uridine may cause GI discomfort or headaches.

How to arrange timing

CDP-Choline already provides uridine. If combining, use a lower dose of Uridine Monophosphate (e.g., 150mg instead of 250mg).

Reference

Reference noted for this combination: Wurtman RJ, et al. Effect of oral CDP-choline on plasma choline and uridine levels in humans. Biochem Pharmacol. 2000;60(7):989-992.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.