Can You Take CBD (Cannabidiol) and Melatonin Together?

Use extra care with this pair

The short answer

CBD may enhance sedation when combined with melatonin, potentially causing excessive drowsiness.

How to arrange timing

Start with low doses if combining and avoid driving.

Reference

Reference noted for this combination: Shannon et al., 2019, Perm J

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.