Can You Take Caffeine and Synephrine Together?

Dose or timing may matter

The short answer

Caffeine and synephrine are both sympathomimetic stimulants that raise blood pressure. Their combined use may produce additive pressor effects and increased cardiovascular strain.

How to arrange timing

Research suggests monitoring blood pressure and heart rate when combining these stimulants. Consider lower doses of each.

Reference

Reference noted for this combination: Stohs SJ et al. Effects of p-synephrine alone and in combination with selected bioflavonoids. Int J Med Sci. 2011;8(4):295-301

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.