Can You Take Caffeine and Nattokinase Together?

Dose or timing may matter

The short answer

Caffeine raises blood pressure via sympathetic activation while nattokinase has mild hypotensive and fibrinolytic effects. Caffeine may counteract nattokinase's BP-lowering benefit.

How to arrange timing

If taking nattokinase for cardiovascular health, consider moderating caffeine intake.

Reference

Reference noted for this combination: Kim JY et al. Effects of nattokinase on blood pressure. Hypertens Res. 2008;31(8):1583-1588

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.