Can You Take Caffeine and GABA Together?

Dose or timing may matter

The short answer

Caffeine blocks adenosine receptors and promotes alertness, which may counteract GABA's calming effects.

How to arrange timing

Separate intake by several hours; caffeine in the morning, GABA in the evening.

Reference

Reference noted for this combination: Clark & Landolt, 2017, Sleep Med Rev

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.