Can You Take Caffeine and Citrulline Together?

Dose or timing may matter

The short answer

Caffeine raises blood pressure via sympathetic activation while citrulline lowers it via nitric oxide production. The opposing effects may partially cancel each other's cardiovascular benefits.

How to arrange timing

Research suggests separating intake by a few hours to allow each supplement to work independently.

Reference

Reference noted for this combination: Wax B et al. Effects of supplemental citrulline malate ingestion during repeated bouts of lower-body exercise. J Strength Cond Res. 2015;29(3):786-792

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.