Can You Take Black Cohosh and Green Tea Extract (EGCG) Together?

Use extra care with this pair

The short answer

Both Green Tea Extract (EGCG) and Black Cohosh have documented hepatotoxic potential. High-dose EGCG causes oxidative hepatocellular injury, while Black Cohosh may trigger autoimmune hepatitis. Combined use may increase liver injury risk.

How to arrange timing

Monitor liver function if using both. Consider using green tea as beverage rather than concentrated EGCG extract when combining with Black Cohosh.

Reference

Reference noted for this combination: Navarro VJ et al., Hepatology 2017; Mahady GB et al., Menopause 2008; LiverTox (NIH/NLM)

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.