Can You Take Apigenin and Melatonin Together?

Use extra care with this pair

The short answer

Apigenin binds GABA-A benzodiazepine receptors; combining with melatonin may cause excessive sedation.

How to arrange timing

Start with low doses if combining for sleep.

Reference

Reference noted for this combination: Salehi et al., 2019, Int J Mol Sci

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.