Can You Take Alpha-Lipoic Acid and Vitamin B1 Together?

Dose or timing may matter

The short answer

Alpha-lipoic acid may reduce circulating thiamine (vitamin B1) levels by enhancing its intracellular metabolism. Research suggests ALA accelerates thiamine phosphorylation, potentially leading to functional deficiency signs.

How to arrange timing

Consider supplementing thiamine when taking high-dose alpha-lipoic acid long-term.

Reference

Reference noted for this combination: Biewenga GP et al. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol. 1997;29(3):315-331

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.